Cgas^em2Npa
Endonuclease-mediated Allele Detail

Summary

• Symbol: Cgas^em2Npa
• Name: cyclic GMP-AMP synthase; endonuclease-mediated mutation 2, Novartis Pharma AG
• MGI ID: MGI:7336101
• Gene: Cgas Location: Chr9:78337808-78350519 bp, - strand Genetic Position: Chr9, 43.65 cM
• Alliance: Cgas^em2Npa page

Mutation origin

• Strain of Origin: Not Specified

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Not Specified
• A null allele was created. (J:328220)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cgas Mutation: 26 strains or lines available

References

• Original: J:328220 Willemsen J, et al., TNF leads to mtDNA release and cGAS/STING-dependent interferon responses that support inflammatory arthritis. Cell Rep. 2021 Nov 9;37(6):109977
• All: 1 reference(s)