Il6^tm1Nzu
Targeted Allele Detail

Summary

• Symbol: Il6^tm1Nzu
• Name: interleukin 6; targeted mutation 1, Janko Nikolich-Zugich
• MGI ID: MGI:7336098
• Synonyms: FAST.B6.IL-6
• Gene: Il6 Location: Chr5:30218112-30224973 bp, + strand Genetic Position: Chr5, 15.7 cM
• Alliance: Il6^tm1Nzu page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:328217
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Inducible)
• Mutation: Insertion
• Mutation details: A construct consisting of a loxP site, FRT site, neo cassette, a Westpahl stop sequence, FRT site, tetO promoter, and loxP site were inserted between the promoter and the first exon of the gene. Expression of the endogenous gene is placed under control of the tetO sequence. (J:328217)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Il6 Mutation: 41 strains or lines available

References

• Original: J:328217 Jergovic M, et al., IL-6 can singlehandedly drive many features of frailty in mice. Geroscience. 2021 Apr;43(2):539-549
• All: 1 reference(s)