Umod^em1Tota
Endonuclease-mediated Allele Detail

Summary

• Symbol: Umod^em1Tota
• Name: uromodulin; endonuclease-mediated mutation 1, Tomoaki Takata
• MGI ID: MGI:7335970
• Gene: Umod Location: Chr7:119061931-119078485 bp, - strand Genetic Position: Chr7, 63.88 cM, cytoband F1-F2
• Alliance: Umod^em1Tota page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR/Cas9 technology targeting exon 2 generated an 81 bp deletion (Chr 7:119077409-119077489) from 21 bp downstream of the start codon (second exon) to 13 bp from the 5 end of the second intron. Western blot analysis confirmed the absence of uromodulin in urine and in the kidney. (J:328144)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Umod Mutation: 10 strains or lines available

References

• Original: J:328144 Takata T, et al., Uromodulin Regulates Murine Aquaporin-2 Activity via Thick Ascending Limb-Collecting Duct Cross-Talk during Water Deprivation. Int J Mol Sci. 2022 Aug 20;23(16)
• All: 1 reference(s)