Wwp1^tm1.2Hkb
Targeted Allele Detail

Summary

• Symbol: Wwp1^tm1.2Hkb
• Name: WW domain containing E3 ubiquitin protein ligase 1; targeted mutation 1.2, Hiroshi Kawabe
• MGI ID: MGI:7332833
• Gene: Wwp1 Location: Chr4:19608303-19708993 bp, - strand Genetic Position: Chr4, 7.56 cM
• Alliance: Wwp1^tm1.2Hkb page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:327431
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Exon 6 was floxed. Recombinase mediated recombination removed the neomycin resistance selection cassette inserted downstream of exon 6 and exon 6. (J:269370)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Wwp1 Mutation: 65 strains or lines available

References

• Original: J:327431 Hoshino S, et al., WWP1 knockout in mice exacerbates obesity-related phenotypes in white adipose tissue but improves whole-body glucose metabolism. FEBS Open Bio. 2020 Mar;10(3):306-315
• All: 2 reference(s)