Igfbp6em1(IMPC)J
Endonuclease-mediated Allele Detail
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Symbol: |
Igfbp6em1(IMPC)J |
Name: |
insulin-like growth factor binding protein 6; endonuclease-mediated mutation 1, Jackson |
MGI ID: |
MGI:7330354 |
Gene: |
Igfbp6 Location: Chr15:102052797-102057946 bp, + strand Genetic Position: Chr15, 57.32 cM
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Alliance: |
Igfbp6em1(IMPC)J page
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IMPC: |
Igfbp6 gene page |
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Strain of Origin: |
C57BL/6NJ
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Project Collection: |
IMPC
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Allele Type: |
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Endonuclease-mediated (Null/knockout) |
Mutation: |
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Intragenic deletion
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Mutation details: This allele was generated at The Jackson Laboratory by electroporating Cas9 protein and 2 guide sequences TTACTGGTAGAAGTGGACCT and GGCAGTCTACTGTATTCCAA, which resulted in a 1866 bp deletion beginning at Chromosome 15 position 102,147,772 bp and ending after 102,149,637 bp (GRCm38/mm10). This mutation deletes ENSMUSE00000285923, ENSMUSE00000133145, and ENSMUSE00000444314 (exons 2-4) and 1277 bp of flanking intronic sequence including the splice acceptor, donor as well as 3UTR is predicted to cause a change of amino acid sequence after residue 112 and early truncation 16 amino acids later.
(J:188991)
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Inheritance: |
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Not Specified |
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View phenotypes and curated references for all genotypes (concatenated display).
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Original: |
J:188991 The Jackson Laboratory, Alleles produced for the KOMP project by The Jackson Laboratory. MGI Direct Data Submission. 2012; |
All: |
2 reference(s) |
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