Etv2^tm1.1Djg
Targeted Allele Detail

Summary

• Symbol: Etv2^tm1.1Djg
• Name: ets variant 2; targeted mutation 1.1, Daniel J Garry
• MGI ID: MGI:7329034
• Synonyms: Etv2^fl
• Gene: Etv2 Location: Chr7:30333041-30335277 bp, - strand Genetic Position: Chr7, 18.92 cM, cytoband A3
• Alliance: Etv2^tm1.1Djg page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:278701
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6 x 129

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted into intron 3 and an FRT and loxP sites flanked neomycin resistance gene cassette downstream of the gene after exon 6. The neo cassette was removed through subsequent flp-mediated recombination, leaving a conditional-ready allele with exons 4-6 floxed. (J:278701)

Expression

In Mice Carrying this Mutation:

8 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Etv2 Mutation: 14 strains or lines available

References

• Original: J:278701 Shi X, et al., The transcription factor Mesp1 interacts with cAMP-responsive element binding protein 1 (Creb1) and coactivates Ets variant 2 (Etv2) gene expression. J Biol Chem. 2015 Apr 10;290(15):9614-25
• All: 3 reference(s)