Mettl3^em1.1Cya
Endonuclease-mediated Allele Detail

Summary

• Symbol: Mettl3^em1.1Cya
• Name: methyltransferase 3, N6-adenosine-methyltransferase complex catalytic subunit; endonuclease-mediated mutation 1.1, Cyagen Biosciences
• MGI ID: MGI:7328945
• Gene: Mettl3 Location: Chr14:52532298-52542585 bp, - strand Genetic Position: Chr14, 26.88 cM, cytoband C1
• Alliance: Mettl3^em1.1Cya page

Mutation origin

• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR/cas9 mediated recombination inserted loxP sites around exons 2 and 3. Cre mediated recombination removed exons 2 and 3 in the germline. (J:326541, J:327184)

Expression

In Mice Carrying this Mutation:

4 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mettl3 Mutation: 39 strains or lines available

References

• Original: J:327184 Xiao Z, et al., The Maternal Microbiome Programs the m(6)A Epitranscriptome of the Mouse Fetal Brain and Intestine. Front Cell Dev Biol. 2022;10:882994
• All: 4 reference(s)