Trgv4^em1Dmuc
Endonuclease-mediated Allele Detail

Summary

• Symbol: Trgv4^em1Dmuc
• Name: T cell receptor gamma, variable 4; endonuclease-mediated mutation 1, Daniel Mucida
• MGI ID: MGI:7328934
• Synonyms: Vgamma4^-
• Gene: Trgv4 Location: Chr13:19369151-19369676 bp, + strand Genetic Position: Chr13, 6.89 cM
• Alliance: Trgv4^em1Dmuc page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• CRISPR/Cas9 technology using sgRNA GUGUAACCAUACACUGGUACCGG generated a 34 bp deletion. (J:101977, J:327132)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Trgv4 Mutation: 10 strains or lines available

References

• Original: J:327132 Reis BS, et al., TCR-Vgammadelta usage distinguishes protumor from antitumor intestinal gammadelta T cell subsets. Science. 2022 Jul 15;377(6603):276-284
• All: 3 reference(s)