Grm1^em2Ljp
Endonuclease-mediated Allele Detail

Summary

• Symbol: Grm1^em2Ljp
• Name: glutamate receptor, metabotropic 1; endonuclease-mediated mutation 2, Louis J Ptacek
• MGI ID: MGI:7328733
• Synonyms: Grm1b-R889W
• Gene: Grm1 Location: Chr10:10561803-10958100 bp, - strand Genetic Position: Chr10, 3.44 cM, cytoband A2
• Alliance: Grm1^em2Ljp page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Not Specified)
• Mutation: Single point mutation
• Mutation details: CRISPR-targeting introduced the mutation responsible for the amino acid substitution of arginine with tryptophan at position 889 (R889W). (J:322811)

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Grm1 Mutation: 81 strains or lines available

References

• Original: J:322811 Shi G, et al., Mutations in Metabotropic Glutamate Receptor 1 Contribute to Natural Short Sleep Trait. Curr Biol. 2021 Jan 11;31(1):13-24.e4
• All: 1 reference(s)