Adrb1^em1Ljp
Endonuclease-mediated Allele Detail

Summary

• Symbol: Adrb1^em1Ljp
• Name: adrenergic receptor, beta 1; endonuclease-mediated mutation 1, Louis J Ptacek
• MGI ID: MGI:7328728
• Synonyms: Adrb1-A187V
• Gene: Adrb1 Location: Chr19:56710549-56713582 bp, + strand Genetic Position: Chr19, 51.96 cM
• Alliance: Adrb1^em1Ljp page

Mutation origin

• Strain of Origin: FVB/N

Mutation description

• Allele Type: Endonuclease-mediated (No functional change)
• Mutation: Single point mutation
• Mutation details: CRISPR-targeting introduced the mutation responsible for the amino acid substitution of alanine with valine at position 187 (A187V). (J:282569)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Adrb1 Mutation: 19 strains or lines available

References

• Original: J:282569 Shi G, et al., A Rare Mutation of beta1-Adrenergic Receptor Affects Sleep/Wake Behaviors. Neuron. 2019 Sep 25;103(6):1044-1055.e7
• All: 2 reference(s)