Ddx41^{tm1c(KOMP)Wtsi}
Targeted Allele Detail

Summary

• Symbol: Ddx41^{tm1c(KOMP)Wtsi}
• Name: DEAD box helicase 41; targeted mutation 1c, Wellcome Trust Sanger Institute
• MGI ID: MGI:7328616
• Synonyms: Ddx41^flox
• Gene: Ddx41 Location: Chr13:55678223-55684471 bp, - strand Genetic Position: Chr13, 30.06 cM
• Alliance: Ddx41^{tm1c(KOMP)Wtsi} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:326963
• Parent Cell Line: JM8A1.N3 (ES Cell)
• Strain of Origin: C57BL/6N-A^tm1Brd

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: Flp-mediated excision of the parental Ddx41^{tm1a(KOMP)Wtsi} allele resulted in the removal of the lacZ and promoter-driven neomycin selection cassette leaving the critical exons 7-9 flanked by loxP sites. Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml. (J:326963)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ddx41 Mutation: 46 strains or lines available

References

• Original: J:326963 Chlon TM, et al., Germline DDX41 mutations cause ineffective hematopoiesis and myelodysplasia. Cell Stem Cell. 2021 Nov 4;28(11):1966-1981.e6
• All: 2 reference(s)