Mad2l2^em1Zhhn
Endonuclease-mediated Allele Detail

Summary

• Symbol: Mad2l2^em1Zhhn
• Name: MAD2 mitotic arrest deficient-like 2; endonuclease-mediated mutation 1, Chun Zhang
• MGI ID: MGI:7328583
• Synonyms: MAD2B^fl
• Gene: Mad2l2 Location: Chr4:148214841-148230156 bp, + strand Genetic Position: Chr4, 78.67 cM, cytoband E1
• Alliance: Mad2l2^em1Zhhn page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Conditional ready, No functional change)
• Mutation: Insertion
• CRISPR-targeting floxed exons 3 and 4. (J:322948)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mad2l2 Mutation: 14 strains or lines available

References

• Original: J:322948 Li MR, et al., MAD2B promotes podocyte injury through regulating Numb-dependent Notch 1 pathway in diabetic nephropathy. Int J Biol Sci. 2022;18(5):1896-1911
• All: 1 reference(s)