Csf1r^em2Uman
Endonuclease-mediated Allele Detail

Summary

• Symbol: Csf1r^em2Uman
• Name: colony stimulating factor 1 receptor; endonuclease-mediated mutation 2, University of Manchester
• MGI ID: MGI:7328553
• Synonyms: Csf1r^E631K
• Gene: Csf1r Location: Chr18:61238644-61264211 bp, + strand Genetic Position: Chr18, 34.41 cM, cytoband D
• Alliance: Csf1r^em2Uman page

Mutation origin

• Strain of Origin: C57BL/6JCrl

Mutation description

• Allele Type: Endonuclease-mediated (Not Specified)
• Mutation: Single point mutation
• Mutation details: CRISPR-targeting introduced the mutation responsible for the amino acid substitution of glutamic acid with lysine at position 631 (E631K). (J:324722)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Csf1r Mutation: 70 strains or lines available

References

• Original: J:324722 Stables J, et al., A kinase-dead Csf1r mutation associated with adult-onset leukoencephalopathy has a dominant inhibitory impact on CSF1R signalling. Development. 2022 Apr 15;149(8):dev200237
• All: 1 reference(s)