Il1b^em1Mora
Endonuclease-mediated Allele Detail

Summary

• Symbol: Il1b^em1Mora
• Name: interleukin 1 beta; endonuclease-mediated mutation 1, Alan R Morrison
• MGI ID: MGI:7328455
• Synonyms: Il-1beta^fl
• Gene: Il1b Location: Chr2:129206490-129213059 bp, - strand Genetic Position: Chr2, 62.97 cM, cytoband F
• Alliance: Il1b^em1Mora page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Conditional ready)
• Mutation: Insertion
• Mutation details: CRISPR/cas9 mediated recombination introduced loxP sites 157 bp upstream and 103 bp downstream of exon 4. (J:327097)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Il1b Mutation: 22 strains or lines available

References

• Original: J:327097 Mantsounga CS, et al., Macrophage IL-1beta promotes arteriogenesis by autocrine STAT3- and NF-kappaB-mediated transcription of pro-angiogenic VEGF-A. Cell Rep. 2022 Feb 1;38(5):110309
• All: 2 reference(s)