Selenos^tm1.1Bcgen
Targeted Allele Detail

Summary

• Symbol: Selenos^tm1.1Bcgen
• Name: selenoprotein S; targeted mutation 1.1, Biocytogen LLC
• MGI ID: MGI:7328454
• Synonyms: Sels^F
• Gene: Selenos Location: Chr7:65729397-65739153 bp, + strand Genetic Position: Chr7, 35.49 cM
• Alliance: Selenos^tm1.1Bcgen page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:323390
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: The targeting construct inserted an FRT-flanked selection cassette with a 3' loxP site and downstream of exon 3 an additional loxP site. Flp-mediated recombination removed the selection cassette and left exon 3 floxed. (J:323390)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Selenos Mutation: 12 strains or lines available

References

• Original: J:323390 Qiao L, et al., Hepatic deficiency of selenoprotein S exacerbates hepatic steatosis and insulin resistance. Cell Death Dis. 2022 Mar 28;13(3):275
• All: 1 reference(s)