Padi4^em1Yqli
Endonuclease-mediated Allele Detail

Summary

• Symbol: Padi4^em1Yqli
• Name: peptidyl arginine deiminase, type IV; endonuclease-mediated mutation 1, Yongqing Li
• MGI ID: MGI:7328442
• Gene: Padi4 Location: Chr4:140473176-140501547 bp, - strand Genetic Position: Chr4, 72.34 cM, cytoband E1
• Alliance: Padi4^em1Yqli page

Mutation origin

• Strain of Origin: C57BL/6J x SJL

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: CRISPR-targeting deleted 65 bp of the genomic sequence and inserted 14 bp resulting in a premature stop codon near the translation initiation codon. (J:323902)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Padi4 Mutation: 46 strains or lines available

References

• Original: J:323902 Tian Y, et al., Peptidylarginine deiminase 2 has potential as both a biomarker and therapeutic target of sepsis. JCI Insight. 2020 Oct 15;5(20)
• All: 2 reference(s)