Slk^tm1.1Lasa
Targeted Allele Detail

Summary

• Symbol: Slk^tm1.1Lasa
• Name: STE20-like kinase; targeted mutation 1.1, Luc A Sabourin
• MGI ID: MGI:7327652
• Synonyms: SLK^fl, SLK^flox
• Gene: Slk Location: Chr19:47568458-47633685 bp, + strand Genetic Position: Chr19, 39.77 cM, cytoband D2
• Alliance: Slk^tm1.1Lasa page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:253620
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6 x 129

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site and an FRT-flanked neomycin cassette were inserted upstream of exon 3 and a second loxP site was inserted downstream of exon 6. The neomycin selection cassette was removed via flp-mediated recombination leaving exons 3-6 floxed. (J:253620)

Expression

In Mice Carrying this Mutation:

55 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Slk Mutation: 57 strains or lines available

References

• Original: J:253620 Pryce BR, et al., Deletion of the Ste20-like kinase SLK in skeletal muscle results in a progressive myopathy and muscle weakness. Skelet Muscle. 2017 Feb 2;7(1):3
• All: 7 reference(s)