Sting1^em1Zhj
Endonuclease-mediated Allele Detail

Summary

• Symbol: Sting1^em1Zhj
• Name: stimulator of interferon response cGAMP interactor 1; endonuclease-mediated mutation 1, Zhengfan Jiang
• MGI ID: MGI:7327537
• Synonyms: Tmem173^-
• Gene: Sting1 Location: Chr18:35866732-35873607 bp, - strand Genetic Position: Chr18, 19.23 cM, cytoband B3
• Alliance: Sting1^em1Zhj page

Mutation origin

• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Nucleotide substitutions
• Mutation details: CRISPR/cas9 mediated recombination using 2 guide RNAs created a 1 bp deletion at guide RNA 1 and a 1 bp insertion at guide RNA 2 resulting in a premature stop codon between the 2 guide RNAs. (J:251075)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sting1 Mutation: 45 strains or lines available

References

• Original: J:251075 Fang R, et al., NEMO-IKKbeta Are Essential for IRF3 and NF-kappaB Activation in the cGAS-STING Pathway. J Immunol. 2017 Nov 1;199(9):3222-3233
• All: 6 reference(s)