Optn^tm1Gshm
Targeted Allele Detail

Summary

• Symbol: Optn^tm1Gshm
• Name: optineurin; targeted mutation 1, Ghanshyam Swarup
• MGI ID: MGI:7327490
• Gene: Optn Location: Chr2:5025453-5068862 bp, - strand Genetic Position: Chr2, 3.15 cM
• Alliance: Optn^tm1Gshm page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:255919
• Parent Cell Line: G4 (ES Cell)
• Strain of Origin: (129S6/SvEvTac x C57BL/6NCrl)F1

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: The targeting construct replaced exon 2 with an FRT site, IRES, lacZ reporter gene, polyadenylation site, floxed neomycin resistance cassette, and an FRT site. (J:255919)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Optn Mutation: 51 strains or lines available

References

• Original: J:255919 Bansal M, et al., Optineurin promotes autophagosome formation by recruiting the autophagy-related Atg12-5-16L1 complex to phagophores containing the Wipi2 protein. J Biol Chem. 2018 Jan 5;293(1):132-147
• All: 2 reference(s)