Ajuba^em1Smbe
Endonuclease-mediated Allele Detail

Summary

• Symbol: Ajuba^em1Smbe
• Name: ajuba LIM protein; endonuclease-mediated mutation 1, Sonja M Best
• MGI ID: MGI:7327435
• Synonyms: Ajuba^- 8216A
• Gene: Ajuba Location: Chr14:54804929-54815015 bp, - strand Genetic Position: Chr14, 27.84 cM, cytoband C1
• Alliance: Ajuba^em1Smbe page

Mutation origin

• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutations: Intragenic deletion, Single point mutation
• Mutation details: CRISPR/Cas9 technology generated a 4 bp deletion (TCCG; 54577209-54577212) and a G to A change (54577214) shortly after the translation initiation codon in exon 1. (J:326970)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ajuba Mutation: 62 strains or lines available

References

• Original: J:326970 Ponia SS, et al., Mitophagy antagonism by ZIKV reveals Ajuba as a regulator of PINK1 signaling, PKR-dependent inflammation, and viral invasion of tissues. Cell Rep. 2021 Oct 26;37(4):109888
• All: 1 reference(s)