Tg(Slc39a8)3Dwn
Transgene Detail

Summary

• Symbol: Tg(Slc39a8)3Dwn
• Name: transgene insertion 3, Daniel W Nebert
• MGI ID: MGI:7327434
• Synonyms: BTZIP8-3
• Transgene: Tg(Slc39a8)3Dwn Location: unknown
• Alliance: Tg(Slc39a8)3Dwn page

Transgene origin

• Strain of Origin: (C57BL/6 x DBA/2)F2

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Slc39a8)3Dwn expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Slc39a8 (MGI:1914797)	Expresses the cadmium-sensitive 129/SvJ-derived allele.

• Mutation details: A BAC from a cadmium-sensitive 129/SvJ library carrying only the mouse Slc39a8 gene was used for pronuclear injection. Lines 3, 5 and 6 were generated, with line 3 studied further. Line 3 mice have an integrated transgene locus containing 3 1 copies of the transgene. (J:125886)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:125886 Wang B, et al., Enhanced cadmium-induced testicular necrosis and renal proximal tubule damage caused by gene-dose increase in a Slc39a8-transgenic mouse line. Am J Physiol Cell Physiol. 2007 Apr;292(4):C1523-35
• All: 3 reference(s)