Chrm1^tm1.1Geno
Targeted Allele Detail

Summary

• Symbol: Chrm1^tm1.1Geno
• Name: cholinergic receptor, muscarinic 1, CNS; targeted mutation 1.1, Genoway
• MGI ID: MGI:7327419
• Synonyms: M1-mEGFP
• Gene: Chrm1 Location: Chr19:8641369-8660970 bp, + strand Genetic Position: Chr19, 5.44 cM
• Alliance: Chrm1^tm1.1Geno page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:326751
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

• Allele Type: Targeted (Conditional ready, Reporter)
• Mutation: Insertion
• Mutation details: The targeting construct inserted a floxed stop cassette containing the fusion with a C-terminal monomeric EGFP reporter gene fusion. Cre-mediated recombination removed the floxed stop cassette. (J:326751)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Chrm1 Mutation: 28 strains or lines available

References

• Original: J:326751 Marsango S, et al., The M1 muscarinic receptor is present in situ as a ligand-regulated mixture of monomers and oligomeric complexes. Proc Natl Acad Sci U S A. 2022 Jun 14;119(24):e2201103119
• All: 1 reference(s)