Sirt3^em1Cya
Endonuclease-mediated Allele Detail

Summary

• Symbol: Sirt3^em1Cya
• Name: sirtuin 3; endonuclease-mediated mutation 1, Cyagen Biosciences
• MGI ID: MGI:7327416
• Gene: Sirt3 Location: Chr7:140443579-140462222 bp, - strand Genetic Position: Chr7, 86.07 cM, cytoband F4
• Alliance: Sirt3^em1Cya page

Mutation origin

• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• CRISPR-targeting deleted exon 4. (J:326759)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Sirt3 Mutation: 32 strains or lines available

References

• Original: J:326759 Zhao J, et al., Mitochondrial PKM2 deacetylation by procyanidin B2-induced SIRT3 upregulation alleviates lung ischemia/reperfusion injury. Cell Death Dis. 2022 Jul 11;13(7):594
• All: 2 reference(s)