Ido1^em1Wgcy
Endonuclease-mediated Allele Detail

Summary

• Symbol: Ido1^em1Wgcy
• Name: indoleamine 2,3-dioxygenase 1; endonuclease-mediated mutation 1, Cong-Yi Wang
• MGI ID: MGI:7327412
• Synonyms: Ido1^flox
• Gene: Ido1 Location: Chr8:25074148-25086987 bp, - strand Genetic Position: Chr8, 12.76 cM
• Alliance: Ido1^em1Wgcy page

Mutation origin

• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Endonuclease-mediated (Conditional ready, No functional change)
• Mutation: Insertion
• CRISPR-targeting floxed exon 4. (J:326766)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ido1 Mutation: 27 strains or lines available

References

• Original: J:326766 Huang T, et al., Adipocyte-derived kynurenine promotes obesity and insulin resistance by activating the AhR/STAT3/IL-6 signaling. Nat Commun. 2022 Jun 17;13(1):3489
• All: 1 reference(s)