Kdm2b^tm1.1Yzhg
Targeted Allele Detail

Summary

• Symbol: Kdm2b^tm1.1Yzhg
• Name: lysine (K)-specific demethylase 2B; targeted mutation 1.1, Yi Zhang
• MGI ID: MGI:7327329
• Synonyms: Kdm2b^2f
• Gene: Kdm2b Location: Chr5:123008727-123127333 bp, - strand Genetic Position: Chr5, 62.63 cM, cytoband F
• Alliance: Kdm2b^tm1.1Yzhg page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:326928
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6 x 129

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: Exon 13 was floxed and an FRT flanked neo cassette was inserted via homologous recombination. Flp mediated recombination removed the neo cassette. (J:326928)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Kdm2b Mutation: 219 strains or lines available

References

• Original: J:326928 Gao Y, et al., Impaired KDM2B-mediated PRC1 recruitment to chromatin causes defective neural stem cell self-renewal and ASD/ID-like behaviors. iScience. 2022 Feb 18;25(2):103742
• All: 1 reference(s)