Zfhx4^{Tn(pb-Act-RFP)1.1Zhu}
Transposon induced Allele Detail

Summary

• Symbol: Zfhx4^{Tn(pb-Act-RFP)1.1Zhu}
• Name: zinc finger homeodomain 4; transposon insertion 1.1, Yuan Zhuang
• MGI ID: MGI:7327328
• Synonyms: Zfhx4^PB
• Gene: Zfhx4 Location: Chr3:5283586-5480917 bp, + strand Genetic Position: Chr3, 1.96 cM, cytoband A1
• Alliance: Zfhx4^{Tn(pb-Act-RFP)1.1Zhu} page

Mutation origin

• Strain of Origin: FVB/NJ

Mutation description

• Allele Type: Transposon induced (Hypomorph, Reporter)
• Mutation: Transposon insertion
• Mutation details: The transposon containing an unspecified hybrid actin promoter driving expression of red fluorescent protein (RFP) flanked by piggyBac-specific left and right terminal sequences was co-injected with a piggyBac-containing transgene to mobilize the transposon. The insertion site is located in the third intron of the gene. qRT-PCR, western blot and immunofluorescence analyses indicated nearly undetectable mRNA and protein expression levels in the brainstem of homozygous mice. (J:123680, J:326576)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Zfhx4 Mutation: 156 strains or lines available

References

• Original: J:326576 Zhang M, et al., Ablation of Zfhx4 results in early postnatal lethality by disrupting the respiratory center in mice. J Mol Cell Biol. 2021 Jul 6;13(3):210-224
• All: 2 reference(s)