Id2^tm1.1Jrk
Targeted Allele Detail

Summary

• Symbol: Id2^tm1.1Jrk
• Name: inhibitor of DNA binding 2; targeted mutation 1.1, Jonathan R Keller
• MGI ID: MGI:7327280
• Synonyms: Id2^fl
• Gene: Id2 Location: Chr12:25143798-25146091 bp, - strand Genetic Position: Chr12, 8.57 cM, cytoband B
• Alliance: Id2^tm1.1Jrk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:326793
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: The targeting construct inserted upstream of exon 1 a loxP site and downstream of exon 2 an FRT-flanked neomycin resistance cassette with a 3' loxP site. Flp-mediated recombination removed the section cassette and leave exons 2 and 3 floxed. (J:326793)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Id2 Mutation: 17 strains or lines available

References

• Original: J:326793 Jakubison BL, et al., ID2 and HIF-1alpha collaborate to protect quiescent hematopoietic stem cells from activation, differentiation, and exhaustion. J Clin Invest. 2022 Jul 1;132(13):e152599
• All: 1 reference(s)