Lrsam1^em1Bhu
Endonuclease-mediated Allele Detail

Summary

• Symbol: Lrsam1^em1Bhu
• Name: leucine rich repeat and sterile alpha motif containing 1; endonuclease-mediated mutation 1, Bo Hu
• MGI ID: MGI:7327136
• Synonyms: Lrsam1^C698R
• Gene: Lrsam1 Location: Chr2:32815228-32851626 bp, - strand Genetic Position: Chr2, 22.09 cM
• Alliance: Lrsam1^em1Bhu page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Not Specified)
• Mutation: Single point mutation
• Mutation details: CRISPR-targeting of exon 26 introduced the mutation (TGC to CGC) responsible for the amino acid substitution of cysteine for arginine at position 694 (C694R). A silent C to A mutation inserted 7 bp upstream of the modified codon. (J:326817)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Lrsam1 Mutation: 32 strains or lines available

References

• Original: J:326817 Moiseev D, et al., C698R mutation in Lrsam1 gene impairs nerve regeneration in a CMT2P mouse model. Sci Rep. 2022 Jul 16;12(1):12160
• All: 1 reference(s)