Stmp1^em1Eno
Endonuclease-mediated Allele Detail

Summary

• Symbol: Stmp1^em1Eno
• Name: short transmembrane mitochondrial protein 1; endonuclease-mediated mutation 1, Eric N Olson
• MGI ID: MGI:7327130
• Synonyms: Mtlbn^-
• Gene: Stmp1 Location: Chr6:35229645-35238574 bp, + strand Genetic Position: Chr6, 15.26 cM
• Alliance: Stmp1^em1Eno page

Mutation origin

• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR/Cas9 technology generated a 20bp deletion in exon 2 of a 47-amino acid protein identified in the noncoding RNA 1810058I24Rik that disrupts the open reading frame and results in a premature stop codon. (J:325962)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Stmp1 Mutation: 4 strains or lines available

References

• Original: J:325962 Makarewich CA, et al., The cardiac-enriched microprotein mitolamban regulates mitochondrial respiratory complex assembly and function in mice. Proc Natl Acad Sci U S A. 2022 Feb 8;119(6):e2120476119
• All: 1 reference(s)