Keap1^tm1Gmdn
Targeted Allele Detail

Summary

• Symbol: Keap1^tm1Gmdn
• Name: kelch-like ECH-associated protein 1; targeted mutation 1, Gina M DeNicola
• MGI ID: MGI:7327097
• Synonyms: Keap1^R554Q
• Gene: Keap1 Location: Chr9:21141026-21150628 bp, - strand Genetic Position: Chr9, 7.74 cM, cytoband A3
• Alliance: Keap1^tm1Gmdn page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:277350
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: (C57BL/6 x 129S4/SvJae)F1

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: The targeting construct inserted a mutation in exon 3 encoding the amino acid substitution of arginine with glutamine at position 554 (R554Q). A floxed exons 3-5 inserted upstream of the modified exon 4. (J:277350)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Keap1 Mutation: 34 strains or lines available

Notes

ES cells = C10 (modified V6.5 containing Col1a1^{tm2(tetO-Pou5f1)Jae})

References

• Original: J:277350 Kang YP, et al., Cysteine dioxygenase 1 is a metabolic liability for non-small cell lung cancer. Elife. 2019 May 20;8:e45572
• All: 2 reference(s)