Stk17b^em2Smoc
Endonuclease-mediated Allele Detail

Summary

• Symbol: Stk17b^em2Smoc
• Name: serine/threonine kinase 17b (apoptosis-inducing); endonuclease-mediated mutation 2, Shanghai Model Organisms Center
• MGI ID: MGI:7327044
• Synonyms: Drak2-Flox, Stk17b^{em1(flox)Smoc}
• Gene: Stk17b Location: Chr1:53794671-53824374 bp, - strand Genetic Position: Chr1, 26.99 cM
• Alliance: Stk17b^em2Smoc page

Mutation origin

• Strain of Origin: C57BL/6JSmoc

Mutation description

• Allele Type: Endonuclease-mediated (Conditional ready, No functional change)
• Mutation: Insertion
• CRISPR-targeting of exon 4 created a floxed allele. (J:325189)
• Inheritance: Not Specified

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Stk17b Mutation: 40 strains or lines available

References

• Original: J:325189 Li Y, et al., DRAK2 aggravates nonalcoholic fatty liver disease progression through SRSF6-associated RNA alternative splicing. Cell Metab. 2021 Oct 5;33(10):2004-2020.e9
• All: 1 reference(s)