Gca^em1Xhl
Endonuclease-mediated Allele Detail

Summary

• Symbol: Gca^em1Xhl
• Name: grancalcin; endonuclease-mediated mutation 1, Xiang-Hang Luo
• MGI ID: MGI:7325475
• Synonyms: Gca^flox
• Gene: Gca Location: Chr2:62494671-62524453 bp, + strand Genetic Position: Chr2, 36.47 cM
• Alliance: Gca^em1Xhl page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Conditional ready, No functional change)
• Mutation: Insertion
• CRISPR-targeting floxed exon 3. (J:325196)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gca Mutation: 17 strains or lines available

References

• Original: J:325196 Li CJ, et al., Senescent immune cells release grancalcin to promote skeletal aging. Cell Metab. 2021 Oct 5;33(10):1957-1973.e6
• All: 3 reference(s)