Pcna^tm2.1Scwh
Targeted Allele Detail

Summary

• Symbol: Pcna^tm2.1Scwh
• Name: proliferating cell nuclear antigen; targeted mutation 2.1, Shao-Chun Wang
• MGI ID: MGI:7325474
• Synonyms: PCNA^211F
• Gene: Pcna Location: Chr2:132091206-132095100 bp, - strand Genetic Position: Chr2, 64.15 cM
• Alliance: Pcna^tm2.1Scwh page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:311101
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: FVB

Mutation description

• Allele Type: Targeted (Not Specified)
• Mutation: Single point mutation
• Mutation details: The targeting construct inserted an FRT-flanked neomycin resistance cassette downstream of exon 4 and a modified exon 5 with the mutation that corresponds to the amino acid substitution of tyrosine with phenylalanine at position 211 (Y211F). Flp-mediated recombination removed the selection cassette. (J:311101, J:325280)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pcna Mutation: 17 strains or lines available

References

• Original: J:311101 Wang YL, et al., Evading immune surveillance via tyrosine phosphorylation of nuclear PCNA. Cell Rep. 2021 Aug 24;36(8):109537
• All: 2 reference(s)