Zfp36^tm1.1Tnr
Targeted Allele Detail

Summary

• Symbol: Zfp36^tm1.1Tnr
• Name: zinc finger protein 36; targeted mutation 1.1, Martin Turner
• MGI ID: MGI:7325470
• Synonyms: Zfp36^fl
• Gene: Zfp36 Location: Chr7:28076208-28078680 bp, - strand Genetic Position: Chr7, 16.72 cM
• Alliance: Zfp36^tm1.1Tnr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:259588
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: The targeting instruction inserted a loxP site upstream of exon 2 and an FRT-flanked neomycin resistance cassette with a 5' loxP site. Flp-mediated recombination removed the selection cassette and left exon 2 floxed. (J:259588)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Zfp36 Mutation: 17 strains or lines available

References

• Original: J:259588 Newman R, et al., Maintenance of the marginal-zone B cell compartment specifically requires the RNA-binding protein ZFP36L1. Nat Immunol. 2017 Jun;18(6):683-693
• All: 4 reference(s)