Nras^em9Burd
Endonuclease-mediated Allele Detail

Summary

• Symbol: Nras^em9Burd
• Name: Nras proto-oncogene, GTPase; endonuclease-mediated mutation 9, Christin Burd
• MGI ID: MGI:7325469
• Synonyms: LSL-Nras^61X
• Gene: Nras Location: Chr3:102965643-102975230 bp, + strand Genetic Position: Chr3, 45.25 cM
• Alliance: Nras^em9Burd page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Conditional ready)
• Mutation: Single point mutation
• Mutation details: CRISPR-targeting introduced the mutation responsible for the amino acid substitution of arginine with a stop codon at position 61 (R61*). (J:325350)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nras Mutation: 40 strains or lines available

References

• Original: J:325350 Murphy BM, et al., Enhanced BRAF engagement by NRAS mutants capable of promoting melanoma initiation. Nat Commun. 2022 Jun 7;13(1):3153
• All: 1 reference(s)