Nptn^em1H
Endonuclease-mediated Allele Detail

Summary

• Symbol: Nptn^em1H
• Name: neuroplastin; endonuclease-mediated mutation 1, Harwell
• MGI ID: MGI:7316909
• Gene: Nptn Location: Chr9:58489504-58560162 bp, + strand Genetic Position: Chr9, 31.79 cM
• Alliance: Nptn^em1H page

Mutation origin

• Strain of Origin: Not Applicable

Mutation description

• Allele Type: Endonuclease-mediated (Modified isoform(s))
• Mutation: Intragenic deletion
• Mutation details: CRISPR/cas9 mediated recombination created a 941 nt deletion removing all of exon 2. Expression of the larger Np65 isoform is lost but the expression of the Np55 isoform is retained. (J:326721)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nptn Mutation: 39 strains or lines available

References

• Original: J:326721 Newton S, et al., Neuroplastin genetically interacts with Cadherin 23 and the encoded isoform Np55 is sufficient for cochlear hair cell function and hearing. PLoS Genet. 2022 Jan;18(1):e1009937
• All: 1 reference(s)