Gata2^tm1Tumg
Targeted Allele Detail

Summary

• Symbol: Gata2^tm1Tumg
• Name: GATA binding protein 2; targeted mutation 1.1, Tohoku University School of Medicine
• MGI ID: MGI:7316573
• Synonyms: G2^R398W
• Gene: Gata2 Location: Chr6:88170873-88184014 bp, + strand Genetic Position: Chr6, 39.2 cM
• Alliance: Gata2^tm1Tumg page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:325406
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: (C57BL/6J x DBA)F1

Mutation description

• Allele Type: Targeted (Not Specified)
• Mutation: Single point mutation
• Mutation details: The targeting mutation introduced the point mutation responsible for the amino acid substitution of arginine with tryptophan at position 398 (R398W). (J:325406)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gata2 Mutation: 29 strains or lines available

References

• Original: J:325406 Hasegawa A, et al., Heterozygous variants in GATA2 contribute to DCML deficiency in mice by disrupting tandem protein binding. Commun Biol. 2022 Apr 19;5(1):376
• All: 1 reference(s)