Pacs2^em2Smoc
Endonuclease-mediated Allele Detail

Summary

• Symbol: Pacs2^em2Smoc
• Name: phosphofurin acidic cluster sorting protein 2; endonuclease-mediated mutation 2, Shanghai Model Organisms Center
• MGI ID: MGI:7316495
• Synonyms: Pacs2^{em1(flox)Smoc}, Pacs-2^fl
• Gene: Pacs2 Location: Chr12:112978128-113038021 bp, + strand Genetic Position: Chr12, 61.57 cM
• Alliance: Pacs2^em2Smoc page

Mutation origin

• Strain of Origin: C57BL/6JSmoc

Mutation description

• Allele Type: Endonuclease-mediated (Conditional ready, No functional change)
• Mutation: Insertion
• CRISPR-targeting floxed exons 6 and 7. (J:325414)
• Inheritance: Not Specified

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pacs2 Mutation: 28 strains or lines available

References

• Original: J:325414 Li C, et al., PACS-2 Ameliorates Tubular Injury by Facilitating Endoplasmic Reticulum-Mitochondria Contact and Mitophagy in Diabetic Nephropathy. Diabetes. 2022 May 1;71(5):1034-1050
• All: 2 reference(s)