Tmem106b^em1Fehu
Endonuclease-mediated Allele Detail

Summary

• Symbol: Tmem106b^em1Fehu
• Name: transmembrane protein 106B; endonuclease-mediated mutation 1, Fenghua Hu
• MGI ID: MGI:7314853
• Synonyms: delta341bp, delta341bp Tmem106b^-
• Gene: Tmem106b Location: Chr6:13069758-13089268 bp, + strand Genetic Position: Chr6, 5.38 cM, cytoband A2
• Alliance: Tmem106b^em1Fehu page

Mutation origin

• Strain of Origin: C57BL/6J x FVB/N

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• CRISPR/Cas9 technology targeting exon 3 generated a 341 bp deletion that includes the start codon. (J:322137)

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tmem106b Mutation: 29 strains or lines available

References

• Original: J:322137 Feng T, et al., A role of the frontotemporal lobar degeneration risk factor TMEM106B in myelination. Brain. 2020 Jul 1;143(7):2255-2271
• All: 6 reference(s)