Lars2^em1Cya
Endonuclease-mediated Allele Detail

Summary

• Symbol: Lars2^em1Cya
• Name: leucyl-tRNA synthetase, mitochondrial; endonuclease-mediated mutation 1, Cyagen Biosciences
• MGI ID: MGI:7314850
• Gene: Lars2 Location: Chr9:123196001-123291731 bp, + strand Genetic Position: Chr9, 73.92 cM, cytoband F
• Alliance: Lars2^em1Cya page

Mutation origin

• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• CRISPR/Cas9 technology targeted exon 4. (J:326207)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Lars2 Mutation: 80 strains or lines available

References

• Original: J:326207 Wang Z, et al., Leucine-tRNA-synthase-2-expressing B cells contribute to colorectal cancer immunoevasion. Immunity. 2022 Jun 14;55(6):1067-1081.e8
• All: 1 reference(s)