Xpa^em1Roer
Endonuclease-mediated Allele Detail

Summary

• Symbol: Xpa^em1Roer
• Name: xeroderma pigmentosum, complementation group A; endonuclease-mediated mutation 1, Axel Roers
• MGI ID: MGI:7314713
• Synonyms: Xpa^delta11, Xpa^KO
• Gene: Xpa Location: Chr4:46175222-46196317 bp, - strand Genetic Position: Chr4, 24.49 cM, cytoband C2
• Alliance: Xpa^em1Roer page

Mutation origin

• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• CRISPR/Cas9 technology generated an 11 bp deletion in exon 4 introducing a frame shift. (J:326465)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Xpa Mutation: 24 strains or lines available

References

• Original: J:326465 Schubert N, et al., Genome Replication Is Associated With Release of Immunogenic DNA Waste. Front Immunol. 2022;13:880413
• All: 1 reference(s)