Trex1^em1Roer
Endonuclease-mediated Allele Detail

Summary

• Symbol: Trex1^em1Roer
• Name: three prime repair exonuclease 1; endonuclease-mediated mutation 1, Axel Roers
• MGI ID: MGI:7314712
• Synonyms: Trex1^delta478
• Gene: Trex1 Location: Chr9:108887000-108888791 bp, - strand Genetic Position: Chr9, 59.63 cM
• Alliance: Trex1^em1Roer page

Mutation origin

• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR/Cas9 technology generated a 478 bp deletion that eliminates the upstream half of the coding region. (J:326465)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Trex1 Mutation: 29 strains or lines available

References

• Original: J:326465 Schubert N, et al., Genome Replication Is Associated With Release of Immunogenic DNA Waste. Front Immunol. 2022;13:880413
• All: 1 reference(s)