Tph1^em1Zfa
Endonuclease-mediated Allele Detail

Summary

• Symbol: Tph1^em1Zfa
• Name: tryptophan hydroxylase 1; endonuclease-mediated mutation 1, Zusen Fan
• MGI ID: MGI:7314677
• Gene: Tph1 Location: Chr7:46294065-46321961 bp, - strand Genetic Position: Chr7, 30.43 cM
• Alliance: Tph1^em1Zfa page

Mutation origin

• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• CRISPR-targeting of exon 2 deleted 13 bp. (J:325980)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tph1 Mutation: 43 strains or lines available

References

• Original: J:325980 Zhu P, et al., 5-hydroxytryptamine produced by enteric serotonergic neurons initiates colorectal cancer stem cell self-renewal and tumorigenesis. Neuron. 2022 May 7
• All: 1 reference(s)