Msx1^em3Imoi
Endonuclease-mediated Allele Detail

Summary

• Symbol: Msx1^em3Imoi
• Name: msh homeobox 1; endonuclease-mediated mutation 3, Issei Imoto
• MGI ID: MGI:7314495
• Synonyms: Msx1⁺¹
• Gene: Msx1 Location: Chr5:37977835-37981929 bp, - strand Genetic Position: Chr5, 20.21 cM
• Alliance: Msx1^em3Imoi page

Mutation origin

• Strain of Origin: C57BL/6 x DBA/2

Mutation description

• Allele Type: Endonuclease-mediated (Not Specified)
• Mutation: Insertion
• Mutation details: CRISPR/cas9 mediated recombination using a guide RNA targeting the upstream region of the Msx homology domain 6 created an frameshift 1 bp insertion. (J:292004)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Msx1 Mutation: 19 strains or lines available

References

• Original: J:292004 Mitsui SN, et al., Novel human mutation and CRISPR/Cas genome-edited mice reveal the importance of C-terminal domain of MSX1 in tooth and palate development. Sci Rep. 2016 Dec 5;6:38398
• All: 1 reference(s)