Keap1^em7Mym
Endonuclease-mediated Allele Detail

Summary

• Symbol: Keap1^em7Mym
• Name: kelch-like ECH-associated protein 1; endonuclease-mediated mutation 7, Masayuki Yamamoto
• MGI ID: MGI:7314413
• Synonyms: Keap1^C288E
• Gene: Keap1 Location: Chr9:21141026-21150628 bp, - strand Genetic Position: Chr9, 7.74 cM, cytoband A3
• Alliance: Keap1^em7Mym page

Mutation origin

• Strain of Origin: (C57BL/6 x DBA)F2

Mutation description

• Allele Type: Endonuclease-mediated (Not Applicable)
• Mutation: Nucleotide substitutions
• Mutation details: CRISPR-targeting introduced the mutation responsible for the amino acid substitution of cysteine with glutamic acid at position 288 (C288E). (J:235914)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Keap1 Mutation: 34 strains or lines available

References

• Original: J:235914 Saito R, et al., Characterizations of Three Major Cysteine Sensors of Keap1 in Stress Response. Mol Cell Biol. 2015 Nov 02;36(2):271-84
• All: 1 reference(s)