Dchs2^tm1.2Hmd
Targeted Allele Detail

Summary

• Symbol: Dchs2^tm1.2Hmd
• Name: dachsous cadherin related 2; targeted mutation 1.2, Hiroshi Hamada
• MGI ID: MGI:7314314
• Gene: Dchs2 Location: Chr3:83035255-83264516 bp, + strand Genetic Position: Chr3, Syntenic
• Alliance: Dchs2^tm1.2Hmd page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:326373
• Parent Cell Line: G4 (ES Cell)
• Strain of Origin: (129S6/SvEvTac x C57BL/6NCrl)F1

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The targeting construct inserted an FRT-flanked neomycin resistance cassette with a 3 loxP site upstream of exon 29 and a single loxP site downstream of the same exon. Flp-mediated recombination removed the selection cassette and cre-mediated recombination removed exon 29. (J:326373)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Dchs2 Mutation: 78 strains or lines available

References

• Original: J:326373 Sai X, et al., Planar cell polarity-dependent asymmetric organization of microtubules for polarized positioning of the basal body in node cells. Development. 2022 May 1;149(9):dev200315
• All: 1 reference(s)