Crmp1^em1Ftan
Endonuclease-mediated Allele Detail

Summary

• Symbol: Crmp1^em1Ftan
• Name: collapsin response mediator protein 1; endonuclease-mediated mutation 1, Fumiaki Tanaka
• MGI ID: MGI:7314270
• Synonyms: Crmp1^ki
• Gene: Crmp1 Location: Chr5:37399402-37449507 bp, + strand Genetic Position: Chr5, 19.96 cM
• Alliance: Crmp1^em1Ftan page

Mutation origin

• Strain of Origin: Not Applicable

Mutation description

• Allele Type: Endonuclease-mediated (Not Specified)
• Mutation: Single point mutation
• Mutation details: CRISPR-targeting introduced the mutation responsible for the amino acid substitution of serine with alanine at position 522 (S522A). (J:326374)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Crmp1 Mutation: 45 strains or lines available

References

• Original: J:326374 Asano T, et al., Inhibition of Crmp1 Phosphorylation at Ser522 Ameliorates Motor Function and Neuronal Pathology in Amyotrophic Lateral Sclerosis Model Mice. eNeuro. 2022 May-Jun;9(3):ENEURO.0133-22.2022
• All: 1 reference(s)