B4galt5^tm1.2Masn
Targeted Allele Detail

Summary

• Symbol: B4galt5^tm1.2Masn
• Name: UDP-Gal:betaGlcNAc beta 1,4-galactosyltransferase, polypeptide 5; targeted mutation 1.2, Masahide Asano
• MGI ID: MGI:7314222
• Synonyms: B4galt5^flox
• Gene: B4galt5 Location: Chr2:167140364-167191103 bp, - strand Genetic Position: Chr2, 87.22 cM, cytoband H3
• Alliance: B4galt5^tm1.2Masn page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:266295
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: The targeting construct inserted a loxP site upstream of exon 4 and downstream of exon 7 an FRT-flanked neomycin resistance cassette with a 5' loxP site. Flp-mediated recombination removed the selection cassette and left exons 4 through 7 floxed. (J:266295)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any B4galt5 Mutation: 24 strains or lines available

References

• Original: J:266295 Yoshihara T, et al., Lactosylceramide synthases encoded by B4galt5 and 6 genes are pivotal for neuronal generation and myelin formation in mice. PLoS Genet. 2018 Aug;14(8):e1007545
• All: 1 reference(s)