Xrcc6^em1Zshn
Endonuclease-mediated Allele Detail

Summary

• Symbol: Xrcc6^em1Zshn
• Name: X-ray repair cross complementing 6; endonuclease-mediated mutation 1, Zhiyuan Shen
• MGI ID: MGI:7314166
• Synonyms: Ku70-K568R
• Gene: Xrcc6 Location: Chr15:81872036-81924286 bp, + strand Genetic Position: Chr15, 38.33 cM, cytoband E-F
• Alliance: Xrcc6^em1Zshn page

Mutation origin

• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Endonuclease-mediated (Not Specified)
• Mutation: Single point mutation
• Mutation details: CRISPR-targeting introduced the mutation (AAG to CGC) resulting in the amino acid substitution of lysine with arginine at position 568 (K568R). (J:326401)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Xrcc6 Mutation: 64 strains or lines available

References

• Original: J:326401 Wang Y, et al., SETD4-mediated KU70 methylation suppresses apoptosis. Cell Rep. 2022 May 10;39(6):110794
• All: 1 reference(s)