Gt(ROSA)26Sor^{em1(CAG-Ppp4r3a)Qili}
Endonuclease-mediated Allele Detail

Summary

• Symbol: Gt(ROSA)26Sor^{em1(CAG-Ppp4r3a)Qili}
• Name: gene trap ROSA 26, Philippe Soriano; endonuclease-mediated mutation 1, Qiji Liu
• MGI ID: MGI:7312041
• Synonyms: PPP4R3A-OE
• Gene: Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
• Alliance: Gt(ROSA)26Sor^{em1(CAG-Ppp4r3a)Qili} page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Conditional ready, Epitope tag, Inserted expressed sequence)
• Mutation: Insertion
• Mutation details: CRISPR-targeting inserted into the locus a CAG promoter, floxed STOP cassette, the Pp4r3a coding region with an HA tag, a WPRE, and polyadenylation sequence. (J:326388)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gt(ROSA)26Sor Mutation: 1089 strains or lines available

References

• Original: J:326388 Gao F, et al., Ppp4r3a deficiency leads to depression-like behaviors in mice by modulating the synthesis of synaptic proteins. Dis Model Mech. 2022 Jun 1;15(6):dmm049374
• All: 1 reference(s)